Our Coronavirus Response and Ongoing Research

The Research Complex at Harwell has remained open throughout the Coronavirus pandemic, with our efforts focussed on supporting research projects in understanding, and ultimately finding effective strategies to defeat the virus. The research scientists based at the Research Complex have been working tirelessly on areas of vaccines and treatments, using their expertise and our unique facilities to bring the Covid-19 pandemic under control.

Thanks to our unique location and access to world-renowned facilities, we believe in cross-disciplinary research and collaboration with our partners across the Harwell Campus throughout these challenging times which has accelerated outstanding results.

Ultimately, science will defeat this virus and all of us at Research Complex, and our wide network of collaborators are endeavouring to play our part in the global effort to end the Coronavirus pandemic.

Published papers to date include:

[1] A potent SARS-CoV-2 neutralising nanobody shows therapeutics efficacy in the Syrian golden hamster model of COVID-19, Jiandong Huo et al., Nature Communications (2021).

[2] Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19, Martin A. Redhead et al., Scientific Reports (2021).

[3] Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 Mpro inhibitors, Tika R. Malla et al., Chemical Communications (2021).

[4] A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection, Ani Miller et al., Scientific Reports (2021).

[5] Correlative multi-scale cryo-imaging unveils SARS-CoV-2 assembly and egress, Luiza Mendonça et al., Nature Communications (2021).

[6] The use of nanobodies in a sensitive ELISA test for SARS-CoV-2 Spike 1 protein, Georgina C. Girt et al., Royal Society Open Science (2021).

[7] A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses, Tiong Kit Tan et al., Nature Communications (2021).

[8] Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2, Jiangdong Huo et al. Nature Structural and Molecular Biology (2020).

[9] Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient, Daming Zhou et al. Nature Structural and Molecular Biology (2020).

[10] Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease, Alice Douangamath et al., Nature Communications (2020).

[11] SARS-CoV-2 Assembly and Egress Pathway Revealed by Correlative Multi-modal Multi-scale Cryo-imaging, Luiza Mendonca et al., bioRxiv (2020).

[12] Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking, Marion Schuller et al., bioXriv (2020).

[13] Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike, Jiandong Huo et al., Cell Host & Microbe (2020).

[14] Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19, Simon P. Graham et al., npj Vaccines (2020).

We welcome scientists to continue working with us and make use of our unique facilities. Please check our guidelines before coming to the Research Complex to conduct your work.

The Research Complex at Harwell (RCaH) is not just a cluster of well-equipped laboratories – it is a place where scientists in the physical sciences, life sciences and laser research work alongside each other, to mutual benefit. The multidisciplinary nature of the work encourages collaborative effort and pollenates ideas between individuals and groups.

The national facilities on site at Harwell enable RCaH in its principal mission, which is to lead and enable world-class research. Those who are already here find that their research has been transformed, simply by being on site.

RCaH welcomes research teams from UK universities to base themselves here, either for the long term or the short term. RCaH also helps facilitate industrial collaborations and can provide access to high quality equipment.