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Biophysical Instruments

The Biophysical Instruments Facility houses a range of equipment for the analysis of the biophysical properties of molecules and their interactions. Techniques available include analytical ultracentrifugation (AUC), surface plasmon resonance (SPR), isothermal titration calorimetry (ITC), light scattering (SEC-MALS) and stopped-flow spectroscopy. The instruments are available to both internal and external users, and to both academic and commercial organisations. The level of support from the facility is tailored to the requirements of each individual user, and ranges from instrument training through to full service work.

Instruments, facilities and expertise

Researchers have access to a broad range of biophysical techniques, including analytical ultracentrifugation (AUC), surface plasmon resonance (SPR), isothermal titration calorimetry (ITC), size-exclusion chromatography with multi-angle light scattering (SEC-MALS) and stopped-flow spectroscopy. Support is tailored to the needs of each project, from instrument training through to fully managed experimental work. Our capabilities continue to evolve, so if you require a particular technique or capability, please contact us to discuss your requirements.

Equipment

Light Scattering

Light scattering is a non-invasive technique for characterizing macromolecules and a wide range of particles in solution. Research...

Flow Induced Dispersion Analysis (FIDA)

Research Complex has a Fida 1 Analyzer from FidaBio, which is an extremely versatile system capable of studying...

Analytical Ultracentrifugation

Research Complex has two Beckman Coulter analytical ultracentrifuges; an Optima AUC and a ProteomeLab XL-I . Both instruments have two integrated detection systems; Rayleigh Interference and Scanning UV/VISIBLE...

Isothermal Titration Calorimetry

Isothermal Titration Calorimetry is a technique that directly measures the heat that is either released or absorbed during the interaction of molecules. Research Complex has two MicroCal manual...

Size-Exclusion Chromatography – Multi-Angle Light Scattering (SEC-MALS)

The interaction of light with matter can give information on the structure and dynamics of that material. Light scattering is a non-invasive technique for characterizing macromolecules and a...

Stopped-flow fluorimeter

In stopped-flow, small volumes of solutions are rapidly driven from syringes into a high efficiency mixer to initiate a fast reaction. The resultant reaction volume displaces the contents...

Surface Plasmon Resonance

Research Complex has a Biacore T200 system that exploits the phenomenon of surface plasmon resonance (SPR) to monitor the interaction between molecules in real time.

Access this facility

Talk to our team about accessing an instrument, arranging training or discussing fully supported experimental work.

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