Research Showcase

RCaH continues to deliver outstanding and impactful science of international quality.

Here are some recent research highlights.

Research Complex at Harwell leads new drug discoveries in neglected tropical disease

Throughout the world, hundreds of millions of people suffer from the disease known as schistosomiasis, which is caused by trematode worms of the genus Schistosoma. Out of the three most medically important species, S. hematobium is the most common species with a presence in 54 countries, particularly in Africa. S. mansoni is endemic in sub-Saharan Africa, Brazil, the…

X-ray imaging during laser additive manufacturing reveals critical findings to improve industry components

Laser powder bed fusion (LPBF) is a form of additive manufacturing (AM) that transforms a 3D digital design into a net-shaped component by selectively fusing powder particles with a focused laser beam, layer upon layer. AM is widely used in many industries, including aerospace, automotive, biomedical, energy and naval sectors due to reduced material waste…

Research into nanobodies from llamas continues to reveal exciting developments in the fight against COVID-19

Key research by a team involving the Research Complex at Harwell into how nanobodies derived from llamas can neutralize the SARS-CoV-2 virus has revealed further how these nanobodies attach to key spike protein the virus uses to attach itself to human cells. Starting with a large library of simple llama antibodies, a large collaborative research…

Collaborative study reveals new details on how bacteria transfer DNA to resist antibiotics

Scientists at the Research Complex at Harwell have collaborated in a study published in Nature Microbiology that reveals new details about how bacteria transfer DNA in order to resist antibiotics. Conjugation is the transfer of genetic material between bacterial cells by direct cell-to-cell contact or by a bridge-like connection between two cells. It facilitates the spread of virulence…