Investigating respiratory pathogens: from cellular modelling of host-pathogen interactions to national surveillance

Arctoris is a biotech services company based in Oxford, Singapore and Boston that applies laboratory automation and computational approaches to accel

Our group is interested in the structural and functional characterisation of membrane proteins that are involved in bacterial multidrug resistance and human diseases. We use protein X-ray crystallography for their structure determination.

We develop and use a variety of biophysical methods to characterise the interactions of biological macromolecules in solution and in the cell. These include proteins (soluble and membrane bound), protein/DNA complexes and nanoparticles.

We use a combination of X-ray crystallography, electron microscopy, biophysical methods and biochemistry to investigate how a variety of different enzymes achieve catalysis.

The Collaborative Computational Project for electron cryo-microscopy (CCP-EM) supports users and developers in biological EM. The three principal aims are:

CCP4 exists to produce and support a world-leading, integrated suite of programs that allows researchers to determine macromolecular structures by X-ray crystallography, and other biophysical techniques.