Seminar Series at Research Complex at Harwell
Steering ultrafast time resolved infrared spectroscopy towards applications in catalysis and energy science
Speaker: Paul Donaldson, Donaldson UKRI-FLF
10am-11am, Wednesday 25th January 2023
Colloquia Series at Research Complex at Harwell
There will be no colloquia taking place in December due to the holiday season.
Past Event Recordings:
Chemist Assisted Robotics – a web application scaling fragment-based designs for drug discovery
Speaker: Warren Thompson, XChem
10am-11am, Wednesday 16th November 2022
X-ray absorption spectral shapes
Sub-500nm resolution IR imaging with Simultaneous Raman and co-located Fluorescence Microscopy – A New Paradigm in Microspectroscopy
Speakers: Dr Mustafa Kaniz, Photothermal Spectroscopy Corp.
10am-11am, Wednesday 9th November 2022
X-ray absorption spectral shapes
Speaker: Professor Frank de Groot, Debye Institute of Nanomaterials Science, Utrecht University, The Netherlands
Wednesday 14th September 2022
Metrology for High Power Laser Manufacturing
Speaker: Dr Brian Simonds, National Institute of Standards and Technology
Wednesday 29th June 2022
Nucleic acid therapeutics – current challenges: An introduction to NATA
Speaker: Dr Nick Lench, Director of NATA
Wednesday 25th May 2022
Zoom recording: https://ukri.zoom.us/rec/share/-FcpwkJkWoBJSQJAbXNUjSZlDObJNkbnoy1Qen-Q5G0H4TRCLbqUKitQPA9OpG_H.BFqaz1F_Zfdrj5BV?startTime=1653469177000
RCaH/Diamond seminar: Characterising biomolecular behaviour by monitoring changes in hydrodynamic radius
Speaker: Dr Henrik Jensen, CSO of Fida Biosystems
11am-12pm, Wednesday 23rd March 2022
Zoom recording: TBC
Tools for protein characterization are in constant development. One of the newest and most exciting tools is the Fida 1 analyzer from Fida Biosystems, which provides both structural information, as well as binding affinities of biomolecules and multi-component complexes ranging from 0.3 to 500 nm in size. The in-solution measurement is buffer independent and can be performed in conditions without any requirement for immobilization.
Recently, new data has been developed for Conformational Changes, Oligomeric State Analysis, Nanobody clone selection, LLPS (Condensates), Targeted Protein Degradation and Nanoparticles. By joining the seminar, you will learn how the Fida 1 analyzer enables you to perform both standard binding characterization and quantification of your biological entity directly in complex matrices.
The seminar will be given by Dr Henrik Jensen, inventor of the FDIA technology and CSO of FIDA Biosystems.
The seminar will be held in Meeting Rooms 1 & 2 here at Research Complex and also via Zoom. We invite colleagues to join in person or virtually.
A Q&A session will be held at the end, followed by refreshments. If you have any questions for our guest speaker, please could you email them either to Alison Oliver or Andrew Quigley by close of Tuesday 22nd March.
RCaH/Diamond seminar: Measuring what really matters: affinity determination in complex samples and with challenging proteins
Speaker: Dr. Sean Devenish
4th November 2021, 10:30-11.30 GMT
Fluidic Analytics is a commercial biotech company originating from the University of Cambridge, established in 2013, and headquartered in Cambridge, UK. Fluidic Analytics provides a unique technology, Microfluidic Diffusional Sizing (MDS), that allows characterisation of proteins and their interactions, including measurements of size, concentration, stoichiometry and binding affinity. Importantly, measurements are performed fully in solution and can be taken directly in complex backgrounds such as cell lysates, serum or plasma. These features have led to MDS yielding valuable data in the area of infectious diseases and immune profiling (antibody detection, affinity/antibody maturation, virus neutralisation, or cross-reactivity studies) as well as studies on challenging proteins (membrane proteins, fibrils, IDPs, etc.).
- Introduction to Microfluidic Diffusional Sizing
- Case study 1: COVID-19: quantitative information the concentration and affinity of antibodies in polyclonal serum samples provides deeper understanding of the immune response to SARS-CoV-2
- Case study 2: Amyloid beta peptide: measuring binding to monomeric and fibrillar forms provides useful insights into the mechanism of action of therapeutic antibodies
- Case study 3: beyond protein-protein interactions: MDS with SMALPs, aptamers, and small molecules
Dr Sean Devenish is Head of Technical Support and Field Applications at Fluidic Analytics. He is responsible for scientific and technical support, as well as delivery of the laboratory services business. He has a PhD in chemistry from the University of Canterbury, New Zealand, and over a decade of postdoctoral experience in biochemistry, biophysics and protein engineering, including six years at the University of Cambridge. Sean has published more than 30 peer-reviewed scientific publications including two in Nature journals. He joined Fluidic Analytics six years ago as the second employee and led the R&D team before moving to the commercial function where he uses his broad and deep knowledge of proteins, assays and our technology to support our valued customers.