Our Coronavirus Response and Ongoing Research
The Research Complex at Harwell has remained open throughout the Coronavirus pandemic, with our efforts focused on supporting research projects in understanding, and ultimately finding effective strategies to defeat the virus. The research scientists based at the Research Complex have been working tirelessly on areas of vaccines and treatments, using their expertise and our unique facilities to bring the Covid-19 pandemic under control.
Thanks to our unique location and access to world-renowned facilities, we believe in cross-disciplinary research and collaboration across the Harwell Campus that throughout these challenging times has delivered outstanding results.
Ultimately, science will defeat this virus and all of us at Research Complex, and our wide network of collaborators are endeavouring to play our part in the global effort to end the Coronavirus pandemic.
Published papers to date include:
 Correlative multi-scale cryo-imaging unveils SARS-CoV-2 assembly and egress, Luiza Mendonça et al., Nature Communications (2021).
 Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2, Jiangdong Huo et al. Nature Structural and Molecular Biology (2020).
 Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient, Daming Zhou et al. Nature Structural and Molecular Biology (2020).
Ongoing research with our collaborators includes the Rosalind Franklin Institute and Protein Production UK on isolating nanobodies – a type of antibody, which can bind to the ‘spike’ protein on the surface of the virus. There is current work with the Electron Bio-Imaging Centre (eBIC) and the Diamond Light Source on understanding virus host cell interactions using the Central Laser Facillity’s (CLF) Octopus Bio-Imaging Facility hosted at Research Complex. In addition, the CLF put out a unique worldwide open call to the CLF’s Octopus Bio-imaging Facility for work into Covid-19. Diamond Light Source researchers in collaboration with the University of Oxford and the Rosalind Franklin Institute have been working on the receptor binding domain of spike protein, polymerase as well as viral proteases. The Research Complex continues to support researchers needing lab access for the rapid access proposals at Diamond to work on Covid-19.
We welcome scientists to continue working with us and make use of our unique facilities. Please check our guidelines before coming to the Research Complex to conduct your work.